Associate Professor
Ph.D. Biomedical Engineering, Georgia Institute of Technology and Emory University 2015
Research Interests
Genome editing
Gene Therapy
In vitro disease models
Point-of-care diagnostic and monitoring tools
Email rcottle@clemson.edu
Office 304 Rhodes Annex
Phone 864-656-3071
The Cottle Group develops cell-based gene therapy technologies and point-of-care devices to improve the lives of patients with inherited metabolic diseases. Our research employs cutting edge techniques from life sciences and bioengineering principles to solve challenging biomedical problems. We are devoted to preparing the next generation of the most capable and ethically responsible bioengineers by providing opportunities for quality research training, professional development, and outreach service activities.
Gene editing approaches to treat diseases
Design of CRISPR-Cas technologies
Targeted gene editing
Off-target analysis using next generation sequencing
Transcriptome analysis
Ex vivo gene editing in hepatocytes
Electroporation-mediated delivery
Lipid nanoparticle-mediated delivery
Engraftment of gene modified hepatocytes in the liver
3D Culture platforms for hepatocytes
Novel functionalized scaffold-based 3D culture system
Spheroid culture system
Disease models of inherited metabolic diseases for drug screening
Diagnostic and monitoring tools for inherited metabolic diseases
Amino acid point-of-care monitoring devices and assays