Profile
James Morris
Genetics and Biochemistry
Professor
864-656-0293
Life Sciences Building 249A [Office]
Life Sciences Building 260B [Lab]
Educational Background
Post-doctoral, Fellow, Johns Hopkins SOM, 2002
Ph.D., Cellular Biology, University of Georgia, 1997
MS, Entomology, University of Georgia, 1992
BS, Biology, College of William and Mary, 1990
Profile/About Me
EPIC Faculty
Courses Taught
GEN3000: Introduction to Genetics for Non-majors
BCHM3050: Introduction to Biochemistry for Non-majors
GEN3020: Introduction to Genetics
GEN3020H: Introduction to Genetics Honors Course
GEN3030: Introduction to Genetics Laboratory
GEN4910: Directed Research in Genetics,
GEN4910H: Honors College course, Directed Research in Genetics.
BCHM4910: Directed Research in Biochemistry
BCHM4910H: Honors College course, Directed Research in Biochemistry
GEN/BCHM8200: Proteomics and Genomics
GEN/BCHM8900: Special Topics, “Molecular Pathogenesisâ€
GEN/BCHM8900: Special Topics, “Molecular Parasitologyâ€
HON2060: "Pandemics: Pending extinction?"
BCHM4430: Molecular and Biochemical Basis for Disease
Selected Publications
Tillery, L, Barret, K, Goldstein, J, Lassner JW, Osterhout, B, Tran, NL, Xu, L, Young, r, Craig, IC, Dranow, DM, Abendroth, J, Delker, SL, Davies, DR, Mayclin, SJ, Calhoun, B, Bolejack, MJ, Staker, B, Subramanian, S, Phan, IQ, Lorimer, DD, Myler, PJ, Edwards, TE, Kyle, DE, Rice, CA, Morris, JC, Leahy, JW, Manetsch, R, Barrett, LK, Van Voorhis, W. Naegleria fowleri: protein structures to facilitate drug discovery for the deadly, pathogenic free-living amoeba. (Accepted, PLoS ONE)
Khalifa, M, Di Genova, M, McAlpine, S, Rozema, S, Monaghan, N, Morris, J, Knoll, L, Golden, J. Dual stage picolinic acid derived inhibitors of Toxoplasma gondii (2020) ACS Medicinal Chemistry Letters 11, 12, 2382-2388. https://doi.org/10.1021/acsmedchemlett.0c00267
Phan, IQ, Rice, CA, Craig, J, Noorai, RE, McDonald, J, Subramanian, S, Tillery, L, Barrett, LK, Shnkar, V, Morris, JC, Van Voorhis, WC, Kyle, DE, Myler, PJ. The transcriptome of Balamuthia mandrillaris trophozoites for structure-based drug design. bioRxiv. doi: https;//doi.org/10.1101/2020.06.29.178905
Srivastava, S, Darling, J, Suryadi, J, Morris, J, Drew, M, Subramaniam, S. Plasmodium vivax and human hexokinases share similar active sites but display distinct quaternary architectures. (2020) IUCrJ, 7, 453-461.
Voyton, C, Choi, J., Qiu, Y., Ackroyd, CP, Morris, MT, Morris, JC, Christensen, KA. A microfluidic-based microscopy platform for continuous interrogation of Trypanosoma brucei during environmental perturbation. (2019) Biochemistry, 58, 875-882.
Milanes, JE, Suryadi, J, Abendroth, J, Van Voorhis, WC, Barrett, KF, Dranow, DM, Phan, IQ, Patrick, SL, Rozema, SD, Khalifa, MM, Golden, JE, Morris, JC. Enzymatic and structural characterization of the Naegleria fowleri glucokinase. (2019) Antimicrobial Agents and Chemotherapy, 63, e02410-18; DOI: 10.1128/AAC.2410-18.
Qiu, Y, Milanes, JE, Jones, JA, Noorai, RE, Shankar, V, Morris, JC. Glucose signaling is important for nutrient adaptation during differentiation of pleomorphic African trypanosomes, (2018) mSphere https://doi.org/10.1128/mSphere.00366-18 (Commentary by Dr. Christine Clayton, mSphere DOI. 10:1128/mSphere.00533-18.)
Voyton, C, Morris, MT, Ackroyd, CP, Morris, JC, Christensen, KA. A FRET flow cytometry-based high throughput screening assay to identify disrupters of glucose levels in Trypanosoma brucei. (2018) ACS Infectious Diseases, 4 (7), 1058-1066.
Voyton, C, Qiu, Y, Morris, MT, Ackroyd, CP, Suryadi, J, Crowe, L, Morris, JC, Christensen, KA. A FRET flow cytometry method for monitoring cytosolic and glycosomal glucose in living kinetoplastid parasites, (2018) PLoS Neglected Tropical Diseases, 12, doi: 10.1371/journal.pntd.0006523.
Flaherty, DP, Harris, MT, Schroeder CE, Khan, H, Kahney, EW, Hackler, A, Patrick, SL, Weiner WS, Aubé J, Sharlow, ER, Morris, JC, Golden, JE. Optimization and evaluation of antiparasitic benzamidobenzoic acids as inhibitors of kinetoplastid hexokinase 1. (2017) ChemMedChem, 12, 1994-2005
Gordhan, HM, Milanes, JE, Qiu, Y, Patrick, SL, Golden, JE, Christensen, KA, Morris, JC, Whitehead, DC. A targeted delivery strategy for the development of potent trypanocides. (2017) Chemical Communications, 53, 8735 - 8738
Lin, S, Voyton, C, Morris, MT, Ackroyd, CP, Morris, JC, Christensen, KA. pH regulation in glycosomes of procyclic form Trypanosoma brucei. (2017) Journal of Biological Chemistry 292, 7795-7805.
Hackler, A, Patrick, SL, Kahney, EW, Flaherty, DP, Sharlow, ER, Morris, JC, Golden, JE.. Antiparasitic lethality of sulfonamidebenzamides in kinetoplastids. (2017) Bioorganic & Medicinal Chemistry Letters 27, 755-758.
Gordhan, HM, Patrick, SL, Swasy, MI, Hackler, AL, Anayee, M, Golden, JE, Morris, JC, Whitehead, D. Evaluation of substituted ebselen derivatives as potential trypanocidal agents, (2017) Bioorganic & Medicinal Chemistry Letters 27, 537-541.
Qiu, Y, Patrick, SL, and Morris JC. Invited Review: Nutrient sensing in kinetoplastid parasites (2016). Advances in Medicine and Biology. Vol 105, 177-202.
Davis, MI, Patrick, SL, Blanding, WM, Dwivedi, V, Suryadi, J, Golden, JE, Coussens, NP, Lee, OW, Shen, M, Boxer, MB, Hall, MD, Sharlow, ER, Drew, ME, Morris JC. Identification of novel Plasmodium falciparum hexokinase inhibitors with anti-parasitic activity, (2016) Antimicrobial Agents and Chemotherapy 60, 6023-6033.