Publications

2024

1. B.A. Ortega Quesada, J. Cuccia, R.N. Coates, B. Nassar, E. Littlefield, E.C. Martin, and A.T. Melvin. “A modular microfluidic platform to study how fluid shear stress alters estrogen receptor phenotype in ER+ breast cancer cells.” Microsystems and Nanoengineering 10:25 (2024)
2. A. Rahnama, M. Vaithiyanathan, L. Briceno-Mena, T.M. Dugas, K.L. Yates, J.A. Romagnoli, and A.T. Melvin. “A microfluidic approach to study variations in Chlamydomonas reinhardtii alkaline phosphatase activity in response to phosphate availability.” Analyst 149:4256-4266 (2024)
3. J. Cuccia, B.A. Ortega Quesada, E.J. Littlefield, A.M. Ham, M.E. Burow, A.T. Melvin, and E.C. Martin. “Loss of hormone receptor expression after exposure to fluid shear stress in breast cancer cell lines.” International Journal of Molecular Sciences 25:13 (2024)

2023

1. H.C. Hymel, J.C. Anderson, D. Liu, T.J. Gauthier, and A.T. Melvin. “Incorporating a β-hairpin sequence motif to increase intracellular stability of a peptide-based PROTAC.” Biochemical Engineering Journal 199:109063 (2023)
2. G. Nelson, A. Strain, A. Isu, A. Rahnama, K. Wakabayashi, A.T. Melvin, and N. Kato. “Cells collectively migrate during ammonium chemotaxis in Chlamydomonas reinhardtii.” Scientific Reports 13: 10781 (2023)

2022

1. A.H. Khan, S.P. Zhou, M. Moe, B.A. Ortega Quesada, K.R. Bajgiran, H.R. Lassiter, J.A. Dorman, E.C. Martin, J.A. Pojman, and A.T. Melvin. "Generation of 3D spheroids using a thiol-acrylate hydrogel scaffold to study endocrine resistance in ER+ breast cancer." ACS Biomaterials Science & Engineering DOI.org/10.1021/acsbiomaterials.2c00491 (2022)
2. H.C. Hymel, A. Rahnama, O.M. Sanchez, D. Liu, T.J. Gauthier, and A.T. Melvin. "How cargo identity alters the uptake of cell penetrating peptide (CPP)/cargo complexes: A study on the effect of net cargo charge and length." Cells 11(7): 1195 (2022)

2021

1. N. da Silva Moura, K.R. Bajgiran, A.T. Melvin, K.M. Dooley, and J.A. Dorman. "Direct probing of Fe₃O₄ nanoparticle surfact temperatures during magnetic heating." ACS Applied Nano Materials 4(12): 13778 (2021)
2. K.R. Bajgiran, A.S. Cordova, R. Elkhanoufi, J.A. Dorman, and A.T. Melvin. "Simultaneous droplet generation with in-series droplet T-junctions induced by gravity-driven flow." Micromachines 12(10):1211 (2021)
3. K.R. Bajgiran, H.C. Hymel, S. Sombolestani, N. Dante, N. Safa, J.A. Dorman, D.N. Rao, and A.T. Melvin. "Fluorescent visulization of oil displacement in a microfluidic device for enhanced oil recovery applications." Analyst (2021) DOI:10.1039/D1AN01333E.
4. S. Sombolestani, B.D. Saikia, A.T. Melvin, and D.N. Rao. "Visualization of spreading and non-spreading oil films in Gas-Assisted Gravity Drainage (GAGD) process using novel NOA81 microfluidic platform." Petroleum & Petrochemical Engineering Journal 5(3):000268 (2021)
5. A.H. Khan, N.M. Smith, M.P. Tullier, B.S. Roberts, D. Englert, J.A. Pojman, and A.T. Melvin. "Development of a flow-free gradient generator using a self-adhesive thiol-acrylate microfluidic resin/hydrogel (TAMR/H) hybrid system." ACS Applied Materials and Interfaces  13(23):26735-26747(2021)
6. N.S. Moura, K.R. Bajgiran, C.L. Roman, L. Daemen, Y. Cheng, J. Lawrence, A.T. Melvin, K.M. Dooley, and J.A. Dorman. "Catalytic enhancement of inductively heated Fe₃O₄ nanoparticles via removal of surface ligands." ChemSusChem 14:1122 (2021)
7. M. Vaithiyanathan, Y. Yu, A. Rahnama, J.H. Pettigrew, N. Safa, D. Liu, T.J. Gauthier, Z.E. Floyd, and A.T. Melvin. "Characterization of PMI-5011 on the regulation of deubiquitinating enzyme activity in multiple myeloma cell extracts." Biochemical Engineering Journal 166:107834 (2021)
8. M. Vaithiyanathan, H.C. Hymel, N. Safa, O.M. Sanchez, J.H. Pettigrew, C.S. Kirkpatrick, T.J. Gauthier, and A.T. Melvin. "Kinetic analysis of cellular internalization and expulsion of unstructured D-chirality cell penetrating peptides." AIChE Journal 67:e17087 (2021)

2020

1. S.M. Rahman, J.M. Campbell, R.N. Coates, K.M. Render, C.E. Byrne, E.C. Martin, and A.T. Melvin. "Evaluation of intercellular communication between breast cancer cells and adipose-derived stem cells via passive diffusion in a two-layer microfluidic device." Lab on a Chip 20:2009 (2020)
2. T. Ofoegbuna, K.R. Bajgiran, O. Kizlikaya, S. Thomas, A.T. Melvin, and J.A. Dorman. "Photoluminescence detection of symmetry transformations in low-dimensional ferroelectric ABO₃ perovskites." Journal of Materials Chemistry C 8:10767 (2020) 
3. C.E Byrne, C.E. Astete, M. Vaithiyanathan, A.T. Melvin, M. Moradipour, S.E. Rankin, B.L. Knutson, C.M. Sabliov, and E.C. Martin. "Lignin-graft-PLGA drug delivery system improves efficacy of MEK1/2 inhibitor in triple negative breast cancer cell line." Nanomedicine 15(10) (2020)
4. K.R. Bajgiran, J.A. Dorman, and A.T. Melvin. "Dipole-modulate downcoversion nanoparticles as label-free biological sensors." ACS Sensors. 5:23-33 (2020)
5. A.H. Khan, J.K. Cook, W.J. Wortmann III, N.D. Kersker, A. Rao, J.A. Pojman, and A.T. Melvin. "Synthesis and characterization of thiol-acrylate hydrogels using a base-catalyzed Michael addition for 3D cell culture applications." Journal of Biomedical Materials Research Part B: Applied Biomaterials. 108B:2294-2307 (2020)
6. Y. Liu, M. Chesnut, A. Guitreau, J. Beckham, A.T. Melvin, J. Eades, T. Tiersch, W.T. Monroe. "Microfabrication of low-cost customisable counting chambers for standardised estimation of sperm concentration." Reproduction, Fertility, and Development. 32(9):873-878 (2020)

2019

1. C. Danielson, G. Pappas, L. Phelps, A.T. Melvin, and K. Park. "Static microdroplet array generated by spraying and analyzed with automated microscopy and image processing." Analytical Biochemistry. 587:113452 (2019)
2. N. Safa, J.H. Pettigrew, T.J. Gauthier, and A.T. Melvin. "Direct quantification of DUB activity in intact cells using a protease-resistant, cell permeable, peptide-based reporter." Biochemical Engineering Journal. 151(15): 107320 (2019)
3. K.R. Bajgiran, P. Darapaneni, A.T. Melvin, and J.A. Dorman. "Effects of weak electric field on the photoluminescence behavior of Bi³⁺-doped YVO₄:Eu³⁺ core-shell nanoparticles." Journal of Physical Chemistry C. 123:13027 (2019)
4. M. Vaithiyanathan, N. Safa, and A.T. Melvin. "FluoroCellTrack: An algorithm for automated analysis of high-throughput droplet microfluidic data." PLOS ONE 14(5) e0215337 (2019)
5. N. Safa, M. Vaithiyanathan, S. Sombolestani, S. Charles, and A.T. Melvin. "Population-based analysis of cell penetrating peptide uptake in a microfluidic droplet trapping array." Analytical and Bioanalytical Chemistry. 411(12) 2729-2741 (2019)
6. M. Vaithiyanathan, K. R. Bajgiran, P. Darapaneni, N. Safa, J.A. Dorman, and A.T. Melvin. "Luminescent nanomaterials for droplet tracking in a microfluidic trapping array." Analytical and Bioanalytical Chemistry. 411 (1) 157-170 (2019)

2018

1. Z. Lamberty, M. Park, N. Macken, and A.T. Melvin. "Transition from planar stratified flow in converging microchannel." Proceedings of the ASME 2018 International Mechanical Engineering Congress and Exposition, IMECE2018-86289, November (2018)
2. G.M. Landwehr, A.J. Kristof, J.H. Pettigrew, S.M. Rahman, J.B. Balhoff, R. Coates, U.L Triantafillu, Y.J. Kim, and A.T. Melvin. "Biophysical analysis of cellular deformation due to fluid shear stress in a microfluidic device," Biomicrofluidics. 12:054109 (2018)
3. J.M. Campbell, J.B. Balhoff, G.M. Landwehr, S.M. Rahman, M. Vaithiyanathan, and A.T. Melvin. "Microfluidic and paper-based devices for disease detection and diagnostic research." International Journal of Molecular Sciences. 19:2731 (2018)
4. J.E. Beckham, F. Alam, V. Omojola, T.F. Scherr, A.M. Guitreau, A.T. Melvin, D. Park, J.W. Choi, T.R. Tiersch, and W.T. Monroe. "A Microfluidic Device for Motility and Osmolality Analysis of Zebrafish Sperm." Biomedical Microdevices 20(3):67 (2018) - link
5. N. Safa, J. C. Anderson, M. Vaithiyanathan, J. H. Pettigrew, G. A. Pappas, D. Liu, T.J. Gauthier, and A.T. Melvin. "CPProtectides: Rapid uptake of well-folded β-hairpin peptides with enhanced resistance to intracellular degradation." Peptide Science, e24092 (2018)

2017

1. K.M. Houston, A.T. Melvin, G.S. Woss, E.L. Fayer, M.L. Waters, and N.L. Allbritton. "Development of β-hairpin peptides for the measurement of SCF-family E3 ligase activity in vitro via ornithine ubiquitination." ACS Omega 2(3): 1198-1206 (2017)

2016

1. A.T. Melvin, L.J. Thibodeaux, A.R. Parsons, E. Overton, K. T. Valsaraj, and K. Nandakumar. "Oil-material fractionation in Gulf deep water horizontal intrusion layer: Field data analysis with chemodynamic fate model for Macondo 252 oil spill." Marine Pollution Bulletin, 105(1), 110-119, (2016)
2. A.T. Melvin, L.D. Dumberger, G.S. Woss, M.L. Waters, and N.L. Allbritton, "Identification of a p53-based portable degron based on the MDM2-p53 binding region." Analyst, 141(2), 570-578, (2016)

2013

1. A.T. Melvin, G.S. Woss, J.H. Park, L.D. Dumberger, M.L. Waters, and N.L. Allbritton, "A comparative analysis of the ubiquitination kinetics of multiple degrons to identify an ideal targeting sequences for a proteasome reporter", PLOS ONE, 8(10), e78082, (2013)
2. A.T. Melvin, G.S. Woss, J.H. Park, M.L. Waters, and N.L. Allbritton, "Measuring activity in the ubiquitin-proteasome system: From large scale discoveries to single cell analysis", Cell Biochemistry and Biophysics, 67(1), 75-89, (2013)
3. M.L. Kovarik, D.M. Ornoff, A.T. Melvin, N.C. Dobes, Y. Wang, A.J. Dickinson, P.C. Gach, P.K. Shah, and N.L. Allbritton, "Micrototal analysis systems: Fundamental advances and applications in the laboratory, clinic, and field", Analytical Chemistry, 85, 451-472, (2013) - link
4. L. Ott, E.J. Sung, A.T. Melvin, M.K. Sheats, J.M. Haugh, K.B. Adler, and S.L. Jones, "Fibroblast migration is regulated by Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) protein", PLOS ONE, 8(6), e66512, (2013)

2012 and earlier

1. E.S. Welf, S. Ahmed, H.E. Johnson, A.T. Melvin, and J.M. Haugh, "Migrating fibroblasts reorient directionality by a metastable, PI3K-dependent mechanism", Journal of Cell Biology, 197, 105-114, (2012) - link
2. A.T. Melvin, E.S. Welf, Y. Wang, D.J. Irvine, and J.M. Haugh, "In chemotaxing fibroblasts, both high-fidelity and weakly biased cell movements track the localization of PI3K signaling", Biophysical Journal, 100, 1893-1901, (2011), featured article
3. M.C. Weiger, C.C. Wang, M. Krajcovic, A.T. Melvin, J.R. Rhoden, and J.M. Haugh, "Spontaneous phosphoinositide 3-kinase signaling dynamics drive spreading and random migration of fibroblasts", Journal of Cell Science, 122, 313-323, (2009)
4. S. Cho, W. Lei, A.T. Melvin, and G.W. Rubloff, "Dynamic simulation and optimization of a Cu CVD unit process for environmentally benign manufacturing", IEEE Transactions on Semiconductor Manufacturing, 17(3), 455-469, (2004)

Teaching/Educational

2024

1. A.T. Melvin, M. Ardoline, and D. Goldgaber. “Development of a learning module to teach chemical engineering students about moral reasoning in the context of process safety.” ASEE Annual Meeting Paper ID 43624 (2024), Portland, OR, U.S.A.
2. A.T. Melvin. “Bioengineering 101: A design challenge to teach high school students about how engineers design and build complex systems.” ASEE Annual Meeting Paper ID 44154 (2024), Portland, OR, U.S.A.

2023

1. A.T. Melvin, M. Dean, and R. Ducksworth, “Fake it until you make it: Lessons learned from the design and implementation of a high school summer research internship program (Evaluation).” ASEE Annual Meeting Paper ID 39197 (2023), Baltimore, MD, U.S.A
2. A.T. Melvin, “Implementation of undergraduate coaches as a student resource in a laboratory course.” ASEE Annual Meeting Paper ID 39700 (2023), Baltimore, MD, U.S.A
3. A. Steele and A.T. Melvin, “ENGage LSU 2.0: Transitioning a field trip experience to a virtual format and its impact on middle school students (Evaluation).” ASEE Annual Meeting Paper ID 39234 (2023), Baltimore, MD, U.S.A

2022

1. A.T. Melvin, "Zoom helpers: A peer-led resource to engage virtual students." Chemical Engineering Education 56(1): 81 (2022)

2021

1. A.T. Melvin and L.G. Bullard, "Fifteen years in the trenches: An updated suite of scenario-based academic integrity videos." Chemical Engineering Education 55(3): 137 (2021)

2019

1. A.T. Melvin and A. Steele, "ENGage LSU: How to organize and implement an engineering outreach day for middle schoolers," Chemical Engineering Education 53(3):162 (2019)

2018

1. B.A. Cicciarelli, E.A. Sherer, and A.T. Melvin, "ChemE Camp: A two-day workshop to increase student preparedness for chemical engineering curricula," Chemical Engineering Education 52(3):181 (2018)
2. A.T. Melvin and L.G. Bullard, "Ten years in the trenches: An updated suite of scenario-based academic integrity videos," 2018 ASEE Annual Conference Proceedings, Paper ID 21231, June (2018)
3. A.T. Melvin and M.G. Benton, "A research experience for undergraduates (REU) program coupling energy-related research with training in entrepreneurship," 2018 ASEE Annual Conference Proceedings, Paper ID 22487, June (2018)

2016

1. A.T. Melvin, "A hands-on approach to teaching K-12 students about microfluidic devices (Work In Progress)", 2016 ASEE Annual Conference Proceedings, Paper ID 16763, June (2016)
2. K. Whittaker, A. Kirtikar, and A.T. Melvin, "ChemE Camp: A two day workshop to increase student preparedness for their sophomore year in chemical engineering (Work In Progress)", 2016 ASEE Annual Conference Proceedings, Paper ID 15854, June (2016)
3. L.G. Bullard and A.T. Melvin, "Using a role-play video to minimize cheating on assignments", Advances in Engineering Education, 2(3), Winter (2011)

2010 and earlier

1. A.T. Melvin, "Tales of a 24th grade nothing: A survivor's guide to graduate school", 2010 ASEE Annual Conference Proceedings, AC 2010-572, June (2010)
2. A.T. Melvin and L.G. Bullard, "Seeing is believing: Using a role-play video to establish expectations for academic integrity", 2009 ASEE Annual Conference Proceedings, AC 2009-266, June (2009)
3. A.T. Melvin and L.G. Bullard, "Tips from the Trenches: Preparation and implementation of an experience-based TA training session", 2008 ASEE Annual Conference Proceedings, AC 2008-610, June (2008)

Patents

2024

1. 1. A. Melvin, J. Pojman, and A. Khan. “Methods and compositions for thiol-acrylate based materials for 3D cell culturing in a microfluidic device”. 17 / 116,289