Profile
Bill Baldwin
Biological Sciences
Professor
864-656-2328
Jordan Hall 318 [Lab]
Long Hall 235 [Office]
Educational Background
PhD, Toxicology, North Carolina State University
BS, Biology, Central Michigan University
Profile/About Me
Dr. Baldwin is a Toxicologist primarily interested in the effects of environmental toxicants on lipid metabolism and utilization. Dr. Baldwin is currently focused on the toxicity of the emerging contaminant, PFOS and other PFAS that perturb fatty acid metabolism.
Dr. Baldwin has more than 75 publications of which more than 40 have been published since 2010. He also serves as a reviewer for NIH and NSF study sections, worked with the Environmental Directorate of the OECD on the testing and assessment of EDCs, NERC for the use of genomics in toxicity assessments and risk assessment, and a government advisory panel on electromagnetic fields. He has also been involved and planned minority educational events as part of the Society of Toxicology and Endocrine Society. Dr. Baldwin is currently a Faculty Fellow in the Graduate Center for Transformational Mentorship (GCTM).
Research Interests
Dr. Baldwin is a Toxicologist primarily interested in the effects of environmental toxicants on lipid metabolism and utilization. Interestingly, energy homeostasis is tightly regulated with individual responses to chemical stress and in turn this energy rich process can cause wasting disease in some instances, while in others may increase obesity and metabolic disease. Activation of specific lipid or toxicant receptors such as PPARs, CAR or PXR, all specific regulators of cytochrome P450s (CYPs) and other detoxification enzymes can perturb energy homeostasis through multiple pathways, including dietary and endocrine signaling.
Dr. Baldwin is currently focused on the toxicity of the emerging contaminant, PFOS, and other endocrine disrupting chemicals (EDCs) that alter oxylipin formation and/or perturb mitochondrial metabolism of fats in skeletal muscle, liver or fat. Our group also recognizes that chemicals typically do not work alone and therefore study the effects of chemical mixtures on energetics and obesity.
Research Group (Lab)
Jazmine Eccles - PhD student studying the role of PFOS and specific oxylipins in altering energy metabolism through changes in PPAR signaling in multiple tissues
Lanie Williams - MS studying the mechanisms the regulate PFOS bioaccumulation in liver, serum, and kidney
Morgan Jacobellis - MS student investigating the effects of common mixtures on childhood obesity using liver and white adipose tissue cell models.
Lexy Kruse - MS student studying new testing methods for urinary tract infections
Courses Taught
BIOL 1010: Frontiers in Biology
ENTOX/BIOSC 8300: Mechanistic Toxicology
BIOL 4800/6800: Endocrinology
BIOL 1030: General Biology
Selected Publications
Select Publications from the Past 5 Years:
Google Scholar: https://scholar.google.com/citations?user=Xyq40g0AAAAJ&hl=en
H-index: 36
i10 index: 59
*Graduate Student Co-Authors
**Undergraduate Student Co-Authors
*Williams, LA; Edin, ML; Lih, FB, *Hamilton, MC; *Eccles-Miller, JA; Tharayil, N; Leonard, E; Baldwin, WS. (2024) Increased PFOS toxicity and accumulation is associated with perturbed prostaglandin metabolism and increased organic anion transport protein (OATP) expression. Toxics, 12, 106. Doi.org/10.3390/toxics12020106.
*Eccles, JA and Baldwin, WS. Metabolism and Function of Oxylipins produced by Cytochrome P450s. Cells. 12(1), 82. doi.org/10.3390/cells1210082
Baldwin, WS, *Davis, TT, *Eccles, JA. Per- and Polyfluoroalkylsubstances (PFAS) and their toxicology as evidenced through disease and biomarkers (2023). In: Biomarkers of Disease: Methods, Discoveries, and Applications. Biomarkers in Toxicology, edited by Rajkumar Rajendram, Vinood B. Patel and Victor R. Preedy. Springer, p. 989-1016. published March 2023. DOI: 10.1007/978-3-030-87225-0. Series ISSN: 2542-3657, Series E ISSN: 2542-3665
*Heintz, MM, **Olack, EM, *Eccles, JA, Maner-Smith, KM, Ortlund, EA, Baldwin, WS. Human CYP2B6 is an anti-obesity enzyme that produces active oxylipins from polyunsaturated fatty acids. PLoS ONE, 17(12) e0277053. doi:10.1371/journal.pone.0277053
**Gessner, EE, **Shah, MH, **Ghent, BN, **Westbrook, NE, van den Hurk, P, Baldwin, WS (2022). The reproductive effects of the cancer chemotherapy agent, Carmofur, on Daphnia magna are mediated by its metabolite, 5-Fluorouracil. Ecotoxicology, 31(5) 860-872. doi: 10.1007/s10646-022-02551-5.
*Heintz, MM, *Kumar, R, Maner-Smith, KM, Ortlund, EA, Baldwin, WS (2022). Age and diet-dependent changes in hepatic lipidomic profiles of male mice: Age acceleration in Cyp2b-null mice. J Lipids, 2022: Article ID 7122738. IF = 1.93. https://doi.org/10.1155/2022/7122738.
**Olack, EM, *Heintz, MM, Baldwin, WS. (2022) Dataset of endo- and xenobiotic inhibition of CYP2B6: Comparison to CYP3A4. Data Brief, 41: 108013.
*Hamilton, MC, *Heintz, MM, *Pfohl, M, *Marques, E, *Ford, L, Slitt, AL, Baldwin, WS. (2021) Increased toxicity and retention of Perfluorooctane Sulfonate (PFOS) in humanized CYP2B6-Transgenic mice compared to Cyp2b-null mice is relieved by a High-Fat Diet (HFD). Food Chem Toxicol, 152, 112175.
Baldwin, WS, Bain, LJ, DiGuilio, R, Kullman, S, Rice, CD Ringwood, AH, van den Hurk, P. (2020) 20th Pollutant responses in marine organisms (PRIMO 20): Global issues and fundamental mechanisms caused by pollutant stress in marine and freshwater organisms. (Review) Aquat Toxicol, 105620.
*Heintz, MM, *Kumar, R, **McRee, R, Baldwin, WS (2020) Gender differences in diet-induced steatotic disease in Cyp2b-null mice. PLoS ONE, 15(3): e0229896
Baldwin, WS. (2019) Phase 0 of the xenobiotic response: Nuclear receptors and other transcription factors as a first step in protection from xenobiotics. Nucl Recept Res, 6: Article ID 101447, 17 pages.
*Heintz, MM, *1Kumar, R, **Rutledge, MM, Baldwin, WS. (2019) Cyp2b-null male mice are susceptible to diet-induced obesity and perturbations in lipid homeostasis. J Nutr Biochem, 70: 125-137.
Rooney, J, Oshida, K, *Kumar, R, Baldwin, W, Corton, JC. (2019) Chemical activation of the constitutive androstane receptor (CAR) leads to activation of oxidant-induced Nrf2. Toxicol Sci, 167: 172-189.
*Schmidt AM, *Sengupta N, Noorai, RE, Saski CA, Baldwin WS. (2017) RNA sequencing indicates that atrazine induces multiple detoxification genes in Daphnia magna and this is a potential source of its mixtures interactions with other chemicals. Chemosphere, 189: 699-708.
*Sengupta, N., **Reardon, D.C., Gerard, P.D., Baldwin, W.S. (2017) Exchange of polar lipids from adults to neonates in Daphnia magna: Perturbations in sphingomyelin allocation by dietary lipids and environmental toxicants. PLOS ONE, 12(5): e0178131.
*Kumar, R., *Mota, L.C., **Litoff, E.J., Rooney, J.P., **Boswell, W.T., **Courter, E., **Henderson, C.M., Hernandez, J.P., Corton, J.C., Moore, D.D., Baldwin, W.S. (2017) Compensatory changes in CYP expression in three different toxicology mouse models: CAR-null, Cyp3a-null, and Cyp2b9/10/13-null mice. PLOS ONE, 12(3): e0174355.
Memberships
Society of Toxicology
Society of Environmental Toxicology and Chemistry
American Association for the Advancement of Science
Outreach
STEM SC
