Profile
Lesly Temesvari
Biological Sciences
Alumni Professor/Assoc Chair
864-656-6387
Life Sciences Building 255B [Office]
Life Sciences Building 260E [Lab]
Educational Background
B.S., Microbiology and Immunology, McGill University, 1987
Ph.D., Biological Sciences, University of Windsor, 1993
Research Interests
The overall goal of the Temesvari laboratory is to understand the molecular mechanisms regulating a virulence in several pathogenic amoebae, Entamoeba histolytica and Acanthamoeba castellanii. These parasites causes amoebic dysentery and liver abscess) and keratitis, respectively. The Temesvari laboratory focuses on parasite-host interactions, the stress response in the parasite, vesicle trafficking, lipid rafts and drug-repurposing.
Courses Taught
Cell Biology (BIOL 4610/6620)
Cell Biology Laboratory (BIOL 4620/6620)
Senior Seminar (BIOL 4930)
CI: Popular Science Journalism (BIOL 4940)
Writing for Graduate Students (BIOL 8490)
Concepts in Molecular, Cellular, and Developmental Biology (BIOL 8010; team taught)
Readings in Molecular, Cellular, and Developmental Biology (BIOL 8070; team taught)
Selected Publications
2022 Walters, H.A.*, Welter, B.H., Knight, E.W., Villano, M.A., Keramatic, C.A.*, Morris, M.T., and Temesvari, L.A. Hypothetical proteins play a role in stage conversion, virulence, and the stress response in the Entamoeba species. Exp. Parasitol. 243:108410. https://doi.org/10.1016/j.exppara.2022.108410.
2022 Walters, H.A.*, Welter, B.H., Moss, H.C.**, Villano, M.A., Orobio-Hurtado, R.*, Sullivan, W.J. Jr., Temesvari, L.A. Eukaryotic Initiation Factor 2? Kinases Regulate Virulence Functions, Stage Conversion, and the Stress Response in Entamoeba invadens. mSphere. 7(3):e0013122. doi: 10.1128/msphere.00131-22.
2021 Karambizi, N.U., McMahan, C.S., Blue, C.N., and Temesvari, L.A. Global estimated Disability-Adjusted Life-Years (DALYs) of diarrheal diseases: A systematic analysis of data from 28 years of the global burden of disease study. PLoS One 16(10):e0259077. doi: 10.1371/journal.pone.0259077.
2021 Walters, H.A., Welter, B.H., Orobio-Hurtado, R., Moss, H.C., Villano, M.A., Sullivan, W.J., Jr., and Temesvari, L.A. EiIF2K-A, a eukaryotic initiation factor 2? kinase, regulates virulence functions, stageconversion, and the stress response in Entamoeba invadens. Revising for PLoS Pathogens (IF=6.218)
2020 Welter B.H., Walters H,A*, and Temesvari L.A. Reduced expression of a rhomboid protease, EhROM1, correlates with changes in the submembrane distribution and size of the Gal/GalNAc lectin subunits in the human protozoan parasite, Entamoeba histolytica. PLoS ONE 15(3): e0219870. https://doi.org/10.1371/journal.pone.0219870 (IF=2.776)
Selected Talks
2024 Studies in the virulence of Entamoeba histolytica and Acanthamoeba castellanii: a tale of two amoebae. Presented at the College of Veterinary Medicine, University of Georgia (February 2024)
2022 Stressed-out Parasites in the Human Gut. Presented to Clemson's Physics Department (November 2022)
2021 Neglected Infections of Poverty. Presented to the Clemson Panhellenic Society (April 2021)
2021 Neglected Infections of Poverty. Presented to the Clemson Engineers for Developing Countries (CEDC) (February 2021)
2020 The stress response in the human protozoan pathogen, Entamoeba histolytica. Presented at the University of Nebraska-Lincoln (October 2020)
Memberships
American Society for Cell Biology
American Society for Microbiology
Sigma Xi
Honors and Awards
2020 Alumni Award for Outstanding Achievement in Research (AAOAR)
2018 Professor of the Game: Clemson-Syracuse football game (September 29, 2018)
2018 Science Discovery Award, College of Science, Clemson University
2010 Fulbright Intercountry Lecturing Award (US-French Fulbright Commission)
2010 Fulbright Intercountry Lecturing Award (US-German Fulbright Commission)
2010 Fulbright Fellowship (US-Italian Fulbright Commission).
