Profile
Qing Liu
Biological Sciences
Assistant Professor
864-656-2328
Jordan Hall 202 [Lab]
Jordan Hall 202A [Research Laboratory Service]
Long Hall 138 [Office]
Educational Background
Postdoc, Genomics, Stanford University School of Medicine
Ph.D., Molecular Toxicology, University of Wisconsin Milwaukee
BS, Biological Sciences, Nanjing University
Profile/About Me
The Liu laboratory focuses on two aspects of the cardiovascular system at both early-life and adult stages, including 1) mechanisms underlying gene regulation and metabolism, and 2) mechanisms of dysfunction in the heart due to exposure to toxicants/pharmaceuticals. We developed a human stem cell-based system to investigate how transcription factors regulate metabolic remodeling (from glycolysis to mitochondrial oxidative phosphorylation) during cardiac differentiation; and we also use human stem cells with CRISPR-technology for genome-wide screening of genes of interest that are involved in exposure. The goal of our research is to fill knowledge gaps in our understanding of the mechanisms of cardiac and metabolic dysfunction due to exposure, and also in the future to benefit predictive toxicology and the prevention of toxicity with respect to human health. Our research integrates both experimental and computational biology with multidisciplinary technologies, including stem cell biology, ‘Omic’ technologies, functional analysis, genome-editing, high-throughput screening, and bioinformatics/computational biology.
Research Interests
Stem cell biology, cardiovascular toxicology and metabolism, genomics
Research Group (Lab)
Postdoc: Yawei Shen
PhD students: Cameron Brown, Xiao Li
Undergraduate students: Andrea Fletcher, Soren Spina, Logan Betenbaugh, Elizabeth Rogers, Lani Hinson, Grace Jenkins, Tae Delaware, Elaine Lin, Susan Lin, Lada Palygina, Jenna Mennona
Lab alumni: Peng Zhang, Meaghan Veale, Maria Baltazar, Zoe Fazio, Luke Tomczak (Med School), Emily Boshaw (Med School), Annabella Jones
Courses Taught
BIOL 4930 Senior Seminar (in Spring)
BIOL 4610 - Cell Biology (in Fall)
BIOL 8070. Readings in MCDB (in Fall)
BIOL 4910 Undergrad Research in Biol Sci
Selected Publications
Zhang P, Liu Y, Li C, Sting LD, Wang P-H, Turnbull MW, Wu H*, Liu Q*. Ectopic expression of SARS-CoV-2 S and ORF-9B proteins alters metabolic profiles and impairs contractile function in cardiomyocytes. Frontiers in Cell and Developmental Biology - Molecular and Cellular Pathology. 2023 (* Corresponding). https://doi.org/10.3389/fcell.2023.1110271
Liu Q*#, Wu H#, Luo Q-J#, Jiang C, Duren, D, Van Bortle K, Zhao M-T, Zhao, B, Liu, J, Marciano DP, Lee-McMullen B, Zhu C, Narasimha AM, Gruber JJ, Lipchik AM, Guo H, Watson NK, Tsai MT, Furihata T, Wei E, Tian L, Li Y, Steinmetz, LM, Wong WH, Kay MA, Wu JC, Snyder MP*. Tyrosine kinase inhibitors induce mitochondrial dysfunction during cardiomyocyte differentiation through alteration of GATA4-mediated networks. BioRxiv preprint: https://www.biorxiv.org/content/10.1101/2020.05.04.077024v1.full; # equal contribution).
Luo W, Adamska J, Verma R, Liu Q, Gupta S, Hagan T, Li C, Feng Y, Valore E, Wang Y, Trisal M, Subramaniam S, Osborne TF, Pulendran B. SREBP signaling is essential for effective B cell responses. Nature Immunology. 2023 Feb;24(2):337-348. doi: 10.1038/s41590-022-01376-y
Van Bortle K, Marciano DP, Liu Q, Lipchik AM, Gollapudi S, Geller B, Monte E, Kamakaka RT, Snyder MP. A cancer-associated RNA Polymerase III identity drives robust transcription and expression of SNAR-A noncoding RNA. Nature Communications. 2022. 13, 3007. https://doi.org/10.1038/s41467-022-30323-6
Grubert F#, Srivas R#, Spacek DV#, Kasowski M#, Greenside P, Narasimha A, Liu Q, Geller B, Sanghi A, Kullik M, Sa S, Rabinovitch M, Dalton S, Snyder MP. Landscape of cohesin-mediated chromatin loops in the human genome. Nature. 2020, 583(7818):737-743. PMID: 32728247 (# equal contribution)
Jiang C#, Wang X#, Li X#, Inlora J#, Wang T#, Liu Q, Snyder MP. Dynamic human exposome revealed by longitudinal personal monitoring. Cell. 2018,175(1):P277-291.E31. PMID: 30241608 (# equal contribution)
Liu Q, Van Bortle K, Zhang Y, Zhao M-T, Zhang JJ, Benjamin GS, Gruber JJ, Jiang C, Wu JC, Snyder MP. Disruption of mesoderm formation during cardiac differentiation due to developmental exposure to 13-cis-retinoic acid. Scientific Reports.2018, 8:12960. PMID: 30154523
Liu Q, Jiang C, Xu J, Zhao M, Van Bortle K, Cheng X, Wang G, Chang HY, Wu JC, Snyder MP. Genome-wide temporal profiling of transcriptome and open chromatin of early cardiomyocyte differentiation derived from hiPSCs and hESCs. Circulation Research. 2017, 121(4): 376-391. PMID: 28663367
Zhao M-T#, Chen H #, Liu Q #, Shao N, Sayed N, Liu C, Kim Y, Yang H, Chour T, Ma H, Gutierrez N, Karakikes I, Mitalipov S, Snyder MP, Wu JC. Molecular and functional resemblance of differentiated cells derived from isogenic human iPSCs and SCNT-derived ESCs. Proceedings of the National Academy of Sciences. 2017. 114(52): E11111-E11120. PMID: 29203658 (# equal contribution)
Memberships
Society of Toxicology
American Heart Association/American Stroke Association
