Faculty Profiles

Brian Butler

Associate Dean of Clinical Programs

Office: Lehotsky Hall
Phone: 864-656-8546
Email: bpbutle@clemson.edu

Education and Training

Residency, Anatomic Pathology, Cornell University

Diplomate ACVP, American College of Veterinary Pathologists

PhD, Comparative Pathology, University of California, Davis

MPH, Public Health, St. George's University, SVM

DVM, Veterinary Medicine, St. George's University, SVM

BS, Biology, University of Missouri

Select Professional Certifications

Rabies Diagnostics Certification, World Health Organization    

Veterinary Leadership Experience, Veterinary Leadership Institute    

Biosecurity Level 3 certification, Cornell University 

Pathology of Mouse Models, The Jackson Laboratory     

Foreign Animal Disease Training, USDA and DHS, Plum Island

Areas of Expertise

Dr. Butler is interested in companion animal surgical pathology with an emphasis on gastrointestinal disease, hepatic pathology, and dermatopathology. Areas of research experience include mucosal immunology with an emphasis on development of animal models of infectious and non-infectious inflammatory intestinal disease.

Publications

2023. Charles KE, Morrall CE, Edwards JJ, Carter KD, Afema JA, Butler BP, Marancik DP. Environmental and Nesting Variables Associated with Atlantic Leatherback Sea Turtle (Dermochelys coriacea) Embryonic and Hatching Success Rates in Grenada, West Indies. Animals. 2023 Feb 16;13(4):685. doi: 10.3390/ani13040685. PMID: 36830474; PMCID: PMC9951857.

2022. Liou MJ, Miller BM, Litvak Y, Nguyen H, Natwick DE, Savage HP, Rixon JA, Mahan SP, Hiyoshi H, Rogers AWL, Velazquez EM, Butler BP, Collins SR, McSorley SJ, Harshey RM, Byndloss MX, Simon SI, Bäumler AJ. Host cells subdivide nutrient niches into discrete biogeographical microhabitats for gut microbes. Cell Host Microbe. 2022 Jun 8;30(6):836-847.e6. doi: 10.1016/j.chom.2022.04.012. Epub 2022 May 13. PMID: 35568027; PMCID: PMC9187619.

2022. V Czaran, J Edwards, J Buchweitz, C Finney, A Chikweto, BP Butler, DP Marancik.
Occurrence of Histamine Toxicity and Metal and Mineral Contaminants in Invasive Lionfish (Pterois volitans) in Grenada, West Indies. Caribbean Journal of Science 52 (1), 114-125.

2022. Bettke JA, Tam JW, Montoya V, Butler BP, van der Velden AWM. Inflammatory Monocytes Promote Granuloma-Mediated Control of Persistent Salmonella Infection. Infect Immun. 2022 Apr 21;90(4):e0007022. doi: 10.1128/iai.00070-22. Epub 2022 Mar 21. PMID: 35311578; PMCID: PMC9022522.

2021. Walker GT, Yang G, Tsai JY, Rodriguez JL, English BC, Faber F, Souvannaseng L, Butler BP, Tsolis RM. Malaria parasite infection compromises colonization resistance to an enteric pathogen by reducing gastric acidity. Sci Adv. 2021 Jun 30;7(27):6232. doi: 10.1126/sciadvabd6232. PMID: 34193410; PMCID: PMC8245046.

2021. James A, Page-Karjian A, Charles KE, Edwards J, Gregory CR, Cheetham S, Buter BP, Marancik DP. Chelonid Alphaherpesvirus 5 Prevalence and First Confirmed Case of Sea Turtle Fibropapillomatosis in Grenada, West Indies. Animals. 2021 May 21;11(6):1490. doi: 10.3390/ani11061490. PMID: 34064092; PMCID: PMC8224268.

2021. JR Frame, B Good, P Slinger, MP Smith, BP Butler, D Marancik. Measuring of the effects of a sea turtle conservation education program on children's knowledge and attitudes in Grenada, West Indies. Ocean & Coastal Management 211, 105752. 2021.

2021. DM Fitzpatrick, MA Tetnowski, TG Rosser, RD Pinckney, DP Marancik, BP Butler. Genetic and morphologic characterization of diaschistorchis pandus (digenea: pronocephalidae) trematodes extracted from hawksbill turtles, Eretmochelys imbricata (Testudines: Cheloniidae), in Grenada, West Indies. The Journal of Parasitology 107 (2), 267-274.

2021. JJ Edwards, VA Amadi, E Soto, MT Jay-Russel, P Aminabadi, K Kenelty, K Charles, G Arya, K Mistry, R Nicholas, BP Butler, D Marancik. Prevalence and phenotypic characterization of Salmonella enterica isolates from three species of wild marine turtles in Grenada, West Indies. Veterinary World. 14 (1), 222.

2020. Miller BM, Liou MJ, Zhang LF, Nguyen H, Litvak Y, Schorr EM, Jang KK, Tiffany CR, Butler BP, Bäumler AJ. Anaerobic Respiration of NOX1-Derived Hydrogen Peroxide Licenses Bacterial Growth at the Colonic Surface. Cell Host Microbe. 2020 Dec 9;28(6):789-797.e5. doi: 10.1016/j.chom.2020.10.009. PMID: 33301718; PMCID: PMC7758056.

2020. Lee JY, Cevallos SA, Byndloss MX, Tiffany CR, Olsan EE, Butler BP, Young BM, Rogers AWL, Nguyen H, Kim K, Choi SW, Bae E, Lee JH, Min UG, Lee DC, Bäumler AJ. High-Fat Diet and Antibiotics Cooperatively Impair Mitochondrial Bioenergetics to Trigger Dysbiosis that Exacerbates Pre-inflammatory Bowel Disease. Cell Host Microbe. 2020 Aug 12;28(2):273-284.e6. doi: 10.1016/j.chom.2020.06.001. Epub 2020 Jul 14. PMID: 32668218; PMCID: PMC7429289.

2020. Bevans AI, Fitzpatrick DM, Stone DM, Butler BP, Smith MP, Cheetham S. Phylogenetic relationships and diversity of bat-associated Leptospira and the histopathological evaluation of these infections in bats from Grenada, West Indies. PLoS Negl Trop Dis. 2020 Jan 21;14(1):e0007940. doi: 10.1371/journal.pntd.0007940. PMID: 31961893; PMCID: PMC6994174.

2018. McLaughlin PA, Bettke JA, Tam JW, Leeds J, Bliska JB, Butler BP, van der Velden AWM. Inflammatory monocytes provide a niche for Salmonella expansion in the lumen of the inflamed intestine. PLoS Pathog. 2019 Jul 15;15(7):e1007847. doi: 10.1371/journal.ppat. 1007847. PMID: 31306468; PMCID: PMC6658010.

2018. Edwards J, Butler BP, Marancik DM. Salmonella enterica in Grenadian marine turtles, a One Health approach. 2018 World Aquatic Veterinary Medical Association annual meeting. Ross University. St. Kitts. Oral presentation.

2018. Diana M. Stone, Amanda Bevans, Dan Fitzpatrick, Butler BP, Sonia Cheetham. Molecular detection and histopathological characterization of zoonotic Leptospira species in bats in Grenada, West Indies. Diseases in Nature Conference, Houston TX. Oral presentation.

2017. Patrick A. McLaughlin, Julie A. Bettke, Jason W. Tam, Joanna D. Luke, Jesse Leeds, James B. Bliska, Butler BP, Adrianus W.M. van der Velden. Contribution of inflammatory monocytes to the pathogenesis of Salmonella-induced colitis. International Congress of Mucosal Immunology, Washington DC. Presentation.

2017. M Kanucka, D Fitzpatrick Butler BP, DM Stone, S Cheetham. Molecular Screening of Zika and Dengue Viruses in Bats (Artibeus spp., Glossophaga longirostris and Molossus molossus) from Grenada, West Indies. SGU Phi Zeta Research Day. 2017. Presentation.

2017. J Edwards, C Morale, Butler BP, D Marancik. Methods and applications for marine turtle disease surveillance in Grenada, West Indies. SGU Phi Zeta Research Day. 2017. Presentation.

2017. J Afema, M Davis, V Amadi, H Hariharan, DM Stone, Butler BP. Staphylococcus pseudintermedius in dogs in Grenada. SGU Phi Zeta Research Day. Presentation.

2017. L Souvannaseng, Butler BP, S Luckhart, RM Tsolis. Effect of non-typhoidal Salmonella infection on risk of malaria parasite transmission in a mouse coinfection model. SGU Phi Zeta Research Day. Presentation.

2017. M Tetnowski, R Pinkney, D Fitzpatrick, D Marancik, BP Butler. Morphological and genetic characterization of intestinal flukes of the Caribbean hawksbill sea turtle, Eretmochelys imbricata. SGU Phi Zeta Research Day. Poster.

2016. N. Taurisano, BP Butler, D. Stone, H. Hariharan, P. J. Fields, H. Ferguson, S. Raverty. Streptococcus phocae infections in marine mammals of the pacific northwest and arctic Canada: a retrospective analysis of 86 post-mortem investigations. Annual Meeting, American College of Veterinary Pathologists. Poster.

2015. Judith A. Appleton, Lucille F. Gagliardo, Dolores E. Hill, Maria A. Gomez– Morales, Elizabeth A. Berliner, Butler BP. Detection of antibodies specific for Trichinella spiralis by competition: one assay for a variety of animal hosts. 14th Annual International Conference on Trichinellosis; Berlin, Germany. Presentation.

2013. Butler BP, Duhamel GE. Canine colorectal polypoid tumors and progression to malignancy. Annual Meeting, American College of Veterinary Pathologists (ACVP). Presentation.

2012. BP Butler, GE Duhamel. Canine colorectal polypoid tumors and progression to malignancy. Annual Meeting, American Association of Veterinary Laboratory Diagnosticians (AAVLD). Presentation. *ACVP Award recipient for best pathology presentation AAVLD, pathology committee.

2012. Butler BP, Tsolis RM. Malaria-induced IL-10 contributes to invasive spread of Salmonella enterica Typhimurium. American Society for Microbiology (ASM). Presentation.

2010. Butler BP, Tsolis RM. Malaria and non-typhoidal Salmonella: Understanding the underlying mechanisms of human co-infection using an animal model. American Society of Tropical Medicine and Hygiene (ASTMH). Presentation.

2009. Butler BP, Tsolis RM. IL-10 elicited during malaria parasite infection blunts the mucosal inflammatory response to non-typhoidal Salmonella. Annual UC Davis Research Symposium: Host-Microbe Interactions. Presentation.

2009. Butler BP, Tsolis RM. Systemic translocation of enteric bacteria and alteration of the microbiome in a mouse model of malaria. Bay Area Microbial Pathogenesis Symposium. Presentation.

Honors and Awards

Phi Zeta - National Veterinary Honor Society, 2005  

NIH T32 Training Grant, 2006 - 2010 

AAVLD, Annual Meeting 2012 – Best Pathology Presentation and Travel Award